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課程名稱 |
細胞微機電及微流體導論
Introduction to Cellular BioMEMS and Biomicrofluidics |
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開課學期 |
102-2 |
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授課對象 |
學程 奈米科技學程 |
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授課教師 |
許聿翔 |
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課號 |
AM7166 |
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課程識別碼 |
543EM5310 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二6,7,8(13:20~16:20) |
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上課地點 |
應107 |
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備註 |
總人數上限：35人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1022cellMEMS |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
課程名稱: 細胞微機電及微流體導論
(Introduction to Cellular BioMEMS and Biomicrofluidics)
1. Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality.
2. Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis.
3. BioMEMS: Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing.
4. Microfluidics: scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media.
5. Special topic: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping.
6. Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration.
7. Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip. |
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課程目標 |
本課程目標為二:
(1) 介紹如何將基礎力學應用在細胞與組織之基礎生物力學分析，並從中解釋其主要機能及物理意義; (2)介紹如何將基礎力學應用在微機電系統及生物微流體流道設計，並應用於細胞力學之研究與醫學上的應用。 |
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課程要求 |
No |
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預期每週課後學習時數 |
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Office Hours |
備註： Project presentation 30%; Midterm 30%; Final project report & Presentation 40 % |
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指定閱讀 |
1. Lecture notes
2. Representative journal papers for the Lab-on-Chip system designed for studying cells and tissues. |
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參考書目 |
Major Reference textbook: Introduction to BioMEMS, Albert Folch, CRC Press; 1st ed. (August 21, 2012)
Ch1 How do we make small things?
Ch2 Micropatterning of substrates and cells
Ch3 Microfluidics
Ch5 Cell-based chips for biotechnology
Ch6 BioMEMS for cell biology
Ch7 Tissue microengineering
Other Reference book：Essential Cell Biology, Bruce Albert, et al. Garland Science, 2nd ed. (September 25, 2003)
Ch17 Cytoskeleton
Ch19 Cell division
Introductory Biomechanics - From Cells to Organisms,
C. Ross Ethier and Craig A. Simmons, Cambridge University Press (April 9, 2007)
Ch2 Cellular biomechanics
Ch3 Hemodynamics
Ch4 The circulatory system
Ch5 Interstitial fluid flow
Fundamental of Microfabrication, Marc Madou, CRC Press
Ch1 Lithography
Ch2 Pattern transfer with dry etching technologies
Ch4 Wet bulk micromachining
Ch5 Surface micromachining.
Theoretical Microfluidics, HenrikBruus, Oxford University Press, (Nov 17, 2007)
Ch2 Governing equations
Ch3 Basic flow solutions
Ch4 Hydraulic resistance and compliance
Ch5 Diffusion |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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Week 1 |
2/18 |
Introduction to Lab-on-a-Chip systems |
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Week 2 |
2/25 |
BioMEMS-Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing |
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Week 3 |
3/04 |
BioMEMS-Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing; Introduction to BioMicrofluidics |
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Week 4 |
3/11 |
BioMicrofluidics - scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media. |
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Week 5 |
3/18 |
Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality. |
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Week 6 |
3/25 |
Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality. |
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Week 7 |
4/01 |
Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis. |
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Week 8 |
4/08 |
Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis. |
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Week 9 |
4/15 |
Special topics: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping. |
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Week 10 |
4/22 |
Midterm |
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Week 11 |
4/29 |
Special topics: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping. |
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Week 12 |
5/06 |
Special topics: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping. |
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Week 13 |
5/13 |
6. Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration. |
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Week 14 |
5/20 |
6. Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration. |
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Week 15 |
5/27 |
6. Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration. |
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Week 16 |
6/03 |
7. Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip. |
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Week 17 |
6/10 |
7. Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip. |
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